| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DMAP1 (1-305) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:4000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DMAP1 |
| Gene ID: |
55929 |
| Uniprot ID: |
DMAP1_HUMAN |
| Immunogen Region: |
1-305 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-305 of human DMAP1 (NP_061973.1). |
| Immunogen Sequence: |
MATGADVRDILELGGPEGDA ASGTISKKDIINPDKKKSKK SSETLTFKRPEGMHREVYAL LYSDKKDAPPLLPSDTGQGY RTVKAKLGSKKVRPWKWMPF TNPARKDGAMFFHWRRAAEE GKDYPFARFNKTVQVPVYSE QEYQLYLHDDAWTKAETDHL FDLSRRFDLRFVVIHDRYDH QQFKKRSVEDLKERYYHICA KLANVRAVPGTDLKIPVFDA GHERRRKEQLERLYNRTPE |
| Function | Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. |
| Protein Name | Dna Methyltransferase 1-Associated Protein 1Dnmap1Dnmt1-Associated Protein 1 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | NucleusCytoplasmTargeted To Replication Foci Throughout S Phase By Dnmt1 |
| Alternative Antibody Names | Anti-Dna Methyltransferase 1-Associated Protein 1 antibodyAnti-Dnmap1 antibodyAnti-Dnmt1-Associated Protein 1 antibodyAnti-DMAP1 antibodyAnti-KIAA1425 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
