| Host: | Rabbit |
| Applications: | WB/IP/FC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM14866 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Purification: | Affinity purification |
| Dilution Range: | WB, 1:500-1:1000IP, 0.5 Mu g-4 Mu g antibody for 400 Mu g-600 Mu g extracts of whole cellsFC, 1:500-1:1000ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requiremen |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DLL4 |
| Gene ID: | 54567 |
| Uniprot ID: | DLL4_HUMAN |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
| Tissue Specificity | Expressed in vascular endothelium. |
| Function | Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis.negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. |
| Protein Name | Delta-Like Protein 4Drosophila Delta Homolog 4Delta4 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2660826Reactome: R-HSA-2691232Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-9013507Reactome: R-HSA-9013700 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Delta-Like Protein 4 antibodyAnti-Drosophila Delta Homolog 4 antibodyAnti-Delta4 antibodyAnti-DLL4 antibodyAnti-UNQ1895 antibodyAnti-PRO4341 antibody |
Information sourced from Uniprot.org