Anti-DKK2 antibody (C-Term) (STJ70136)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-DKK2 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 28kDa band observed in Human Heart lysate (calculated MW of 28.5kDa according to NP_055236). Recommended concentration: 1-3µg/ml |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | DKK2 |
| Gene ID | 27123 |
| Uniprot ID | DKK2_HUMAN |
| Accession Number | NP_055236.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | ATYSSKARLHVCQKI |
| Specificity | From sequence analysis it is possible that this product will crossreact with DKK4, unfortunately this has not yet been specifically tested. |
Additional Info
| Post Translational Modifications | May be proteolytically processed by a furin-like protease. |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Protein Name | Dickkopf-Related Protein 2Dickkopf-2Dkk-2Hdkk-2 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470Reactome: R-HSA-5339717 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Dickkopf-Related Protein 2 antibodyAnti-Dickkopf-2 antibodyAnti-Dkk-2 antibodyAnti-Hdkk-2 antibodyAnti-DKK2 antibodyAnti-UNQ682 antibodyAnti-PRO1316 antibody |
Information sourced from Uniprot.org