Anti-DKK1 antibody [R07-6J6] (STJA0036059)

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STJA0036059
£133.50 - £281.50
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Host: Rabbit
Applications: WB/IHC-P/ICC/IF/FC
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal anti-DKK1 for use in WB, IHC-P, ICC, IF and FC in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : R07-6J6
Conjugation: Unconjugated
Isotype: IgG
Formulation: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification: Affinity Chromatography
Dilution Range: WB 1:500-1:1000
IHC 1:50-1:100
IF 1:50-1:200
FC 1:50-1:100
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: DKK1
Gene ID: 22943
Uniprot ID: DKK1_HUMAN
Immunogen: A synthesized peptide derived from human DKK1
Tissue Specificity Placenta.
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity.
Protein Name Dickkopf-Related Protein 1
Dickkopf-1
Dkk-1
Hdkk-1
Sk
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-3772470
Reactome: R-HSA-5339717
Cellular Localisation Secreted
Alternative Antibody Names Anti-Dickkopf-Related Protein 1 antibody
Anti-Dickkopf-1 antibody
Anti-Dkk-1 antibody
Anti-Hdkk-1 antibody
Anti-Sk antibody
Anti-DKK1 antibody
Anti-UNQ492 antibody
Anti-PRO1008 antibody

Information sourced from Uniprot.org

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