Anti-DISC1 antibody (423-473 aa) (STJ193954)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human DISC1 at the amino acid range 423-473
General Information
| Short Description | Rabbit polyclonal anti-Disrupted in schizophrenia 1 protein (423-473 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DISC1 |
| Gene ID | 27185 |
| Uniprot ID | DISC1_HUMAN |
| Immunogen | Synthesized peptide derived from the human DISC1 at the amino acid range 423-473 |
| Immunogen Region | 423-473 aa |
| Specificity | This antibody detects endogenous levels of DISC1 at Human/Mouse/Rat |
Additional Info
| Post Translational Modifications | Ubiquitinated. Ubiquitination with 'Lys-48'-linked polyubiquitin chains leads to its proteasomal degradation. |
| Function | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding. Plays a role, together with PCNT, in the microtubule network formation. |
| Protein Name | Disrupted In Schizophrenia 1 Protein |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMitochondrionMicrotubule Organizing CenterCentrosomePostsynaptic DensityColocalizes With Ndel1 In The Perinuclear Region And The CentrosomeLocalizes To Punctate Cytoplasmic Foci Which Overlap In Part With MitochondriaColocalizes With Pcnt At The Centrosome |
| Alternative Antibody Names | Anti-Disrupted In Schizophrenia 1 Protein antibodyAnti-DISC1 antibodyAnti-KIAA0457 antibody |
Information sourced from Uniprot.org