| Post Translational Modifications | Phosphorylated. Phosphorylation does not inhibit catalytic activity. |
| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization. |
| Protein Name | Diacylglycerol Kinase EtaDag Kinase EtaDiglyceride Kinase EtaDgk-Eta |
| Database Links | Reactome: R-HSA-114508 |
| Cellular Localisation | CytoplasmCell MembraneTranslocated From The Cytoplasm To Endosomes In Response To Stress StimuliIsoform 2 Is Rapidly Relocated Back To The Cytoplasm Upon Removal Of Stress StimuliWhereas Isoform 1 Exhibits Sustained Endosomal AssociationTranslocates From The Cytoplasm To The Cell Membrane In The Presence Of Active Gtp-Bound Form Of Hras |
| Alternative Antibody Names | Anti-Diacylglycerol Kinase Eta antibodyAnti-Dag Kinase Eta antibodyAnti-Diglyceride Kinase Eta antibodyAnti-Dgk-Eta antibodyAnti-DGKH antibody |
Information sourced from Uniprot.org
