| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DGKB (544-773) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DGKB |
| Gene ID: |
1607 |
| Uniprot ID: |
DGKB_HUMAN |
| Immunogen Region: |
544-773 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 544-773 of human DGKB (NP_663733.1). |
| Immunogen Sequence: |
LMKILKDIENSTEIMLDRWK FEVIPNDKDEKGDPVPYSII NNYFSIGVDASIAHRFHIMR EKHPEKFNSRMKNKFWYFEF GTSETFSATCKKLHESVEIE CDGVQIDLINISLEGIAILN IPSMHGGSNLWGESKKRRSH RRIEKKGSDKRTTVTDAKEL KFASQDLSDQLLEVVGLEGA MEMGQIYTGLKSAGRRLAQC SCVVIRTSKSLPMQIDGEPW MQTPCTVSTE |
| Tissue Specificity | Isoform 1: Specifically expressed in brain but also detected in uterus. In adult brain, expressed in the amygdala, caudate nucleus, and hippocampus. Isoform 2: More ubiquitously expressed but at lower level compared to isoform 1. |
| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol. Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation. Isoform 2: Does not associate with membranes but has a diacylglycerol kinase activity. |
| Protein Name | Diacylglycerol Kinase BetaDag Kinase Beta90 Kda Diacylglycerol KinaseDiglyceride Kinase BetaDgk-Beta |
| Database Links | Reactome: R-HSA-114508 |
| Cellular Localisation | Postsynaptic Cell MembranePeripheral Membrane ProteinCell MembraneCytoplasmTranslocation To The Plasma Membrane Is Induced By Phorbol EstersIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Diacylglycerol Kinase Beta antibodyAnti-Dag Kinase Beta antibodyAnti-90 Kda Diacylglycerol Kinase antibodyAnti-Diglyceride Kinase Beta antibodyAnti-Dgk-Beta antibodyAnti-DGKB antibodyAnti-DAGK2 antibodyAnti-KIAA0718 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
