| Function | Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats. In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage. Also present in female mammary glands, where it produces fat in the milk. May be involved in VLDL (very low density lipoprotein) assembly. In contrast to DGAT2 it is not essential for survival. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG). |
| Protein Name | Diacylglycerol O-Acyltransferase 1Acat-Related Gene Product 1Acyl-Coa Retinol O-Fatty-AcyltransferaseAratRetinol O-Fatty-AcyltransferaseDiglyceride Acyltransferase |
| Database Links | Reactome: R-HSA-1482883Reactome: R-HSA-6798695Reactome: R-HSA-75109 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Diacylglycerol O-Acyltransferase 1 antibodyAnti-Acat-Related Gene Product 1 antibodyAnti-Acyl-Coa Retinol O-Fatty-Acyltransferase antibodyAnti-Arat antibodyAnti-Retinol O-Fatty-Acyltransferase antibodyAnti-Diglyceride Acyltransferase antibodyAnti-DGAT1 antibodyAnti-AGRP1 antibodyAnti-DGAT antibody |
Information sourced from Uniprot.org
