| Post Translational Modifications | The three-dimensional structure formed by the three intramolecular disulfide bridges is indispensable for antimicrobial activity. |
| Function | Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E.coli and S.typhimurium, and Gram-positive bacteria, such as S.aureus and B.subtilis. Inhibits cell adhesion of E.coli on intestinal epithelial enterocytes. Causes rapid permeabilization of both the outer and inner membrane of E.coli, leading to morphological alterations on the bacterial surface. Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization. May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms. |
| Protein Name | Defensin Beta 118Beta-Defensin 18Defb-18Epididymal Secretory Protein 13.6Esp13.6 |
| Database Links | Reactome: R-HSA-1461957Reactome: R-HSA-1461973 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Defensin Beta 118 antibodyAnti-Beta-Defensin 18 antibodyAnti-Defb-18 antibodyAnti-Epididymal Secretory Protein 13.6 antibodyAnti-Esp13.6 antibodyAnti-DEFB118 antibodyAnti-C20orf63 antibodyAnti-DEFB18 antibodyAnti-ESC42 antibody |
Information sourced from Uniprot.org
