| Host: | Rabbit |
| Applications: | IHC/IF |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Beta-defensin 114 (6-56 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-200IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DEFB114 |
| Gene ID: | 245928 |
| Uniprot ID: | DB114_HUMAN |
| Immunogen Region: | 6-56 aa |
| Specificity: | This antibody detects endogenous levels of DB114 at Human |
| Immunogen: | Synthesized peptide derived from the human DB114 at the amino acid range 6-56 |
| Function | Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. |
| Protein Name | Beta-Defensin 114Beta-Defensin 14Defb-14Defensin - Beta 114 |
| Database Links | Reactome: R-HSA-1461957Reactome: R-HSA-1461973 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Beta-Defensin 114 antibodyAnti-Beta-Defensin 14 antibodyAnti-Defb-14 antibodyAnti-Defensin - Beta 114 antibodyAnti-DEFB114 antibodyAnti-DEFB14 antibody |
Information sourced from Uniprot.org
