Anti-DEDD antibody (90-170 aa) (STJ191839)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 90-170
General Information
| Short Description | Rabbit polyclonal anti-Death effector domain-containing protein (90-170 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DEDD |
| Gene ID | 9191 |
| Uniprot ID | DEDD_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 90-170 |
| Immunogen Region | 90-170 aa |
| Specificity | DEDD Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Exists predominantly in a mono- or diubiquitinated form. |
| Function | A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro. |
| Protein Name | Death Effector Domain-Containing ProteinDedpro1Death Effector Domain-Containing Testicular MoleculeFlded-1 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusNucleolusTranslocated To The Nucleus During Cd95-Mediated Apoptosis Where It Is Localized In The NucleoliFollowing Apoptosis InductionThe Mono And/Or Diubiquitination Form Increases And Forms Filamentous Structures That Colocalize With Krt8 And Krt18 Intermediate Filament Network In Simple Epithelial Cells |
| Alternative Antibody Names | Anti-Death Effector Domain-Containing Protein antibodyAnti-Dedpro1 antibodyAnti-Death Effector Domain-Containing Testicular Molecule antibodyAnti-Flded-1 antibodyAnti-DEDD antibodyAnti-DEDPRO1 antibodyAnti-DEFT antibodyAnti-KE05 antibody |
Information sourced from Uniprot.org