| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DEDD |
| Gene ID: | 9191 |
| Uniprot ID: | DEDD_HUMAN |
| Immunogen Region: | 1-318 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human DEDD (NP_001034801.1). |
| Immunogen Sequence: | MAGLKRRASQVWPEEHGEQE HGLYSLHRMFDIVGTHLTHR DVRVLSFLFVDVIDDHERGL IRNGRDFLLALERQGRCDES NFRQVLQLLRIITRHDLLPY VTLKRRRAVCPDLVDKYLEE TSIRYVTPRALSDPEPRPPQ PSKTVPPHYPVVCCPTSGPQ MCSKRPARGRATLGSQRKRR KSVTPDPKEKQTCDIRLRVR AEYCQHETALQGNVFSNKQD PLERQFERFNQANTILKSR |
| Tissue Specificity | Widely expressed with highest levels in testis. |
| Post Translational Modifications | Exists predominantly in a mono- or diubiquitinated form. |
| Function | A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro. |
| Protein Name | Death Effector Domain-Containing Protein Dedpro1 Death Effector Domain-Containing Testicular Molecule Flded-1 |
| Cellular Localisation | Cytoplasm Nucleus Nucleolus Translocated To The Nucleus During Cd95-Mediated Apoptosis Where It Is Localized In The Nucleoli Following Apoptosis Induction The Mono And/Or Diubiquitination Form Increases And Forms Filamentous Structures That Colocalize With Krt8 And Krt18 Intermediate Filament Network In Simple Epithelial Cells |
| Alternative Antibody Names | Anti-Death Effector Domain-Containing Protein antibody Anti-Dedpro1 antibody Anti-Death Effector Domain-Containing Testicular Molecule antibody Anti-Flded-1 antibody Anti-DEDD antibody Anti-DEDPRO1 antibody Anti-DEFT antibody Anti-KE05 antibody |
Information sourced from Uniprot.org