| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DEDD (1-318) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DEDD |
| Gene ID: |
9191 |
| Uniprot ID: |
DEDD_HUMAN |
| Immunogen Region: |
1-318 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human DEDD (NP_001034801.1). |
| Immunogen Sequence: |
MAGLKRRASQVWPEEHGEQE HGLYSLHRMFDIVGTHLTHR DVRVLSFLFVDVIDDHERGL IRNGRDFLLALERQGRCDES NFRQVLQLLRIITRHDLLPY VTLKRRRAVCPDLVDKYLEE TSIRYVTPRALSDPEPRPPQ PSKTVPPHYPVVCCPTSGPQ MCSKRPARGRATLGSQRKRR KSVTPDPKEKQTCDIRLRVR AEYCQHETALQGNVFSNKQD PLERQFERFNQANTILKSR |
| Tissue Specificity | Widely expressed with highest levels in testis. |
| Post Translational Modifications | Exists predominantly in a mono- or diubiquitinated form. |
| Function | A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro. |
| Protein Name | Death Effector Domain-Containing ProteinDedpro1Death Effector Domain-Containing Testicular MoleculeFlded-1 |
| Cellular Localisation | CytoplasmNucleusNucleolusTranslocated To The Nucleus During Cd95-Mediated Apoptosis Where It Is Localized In The NucleoliFollowing Apoptosis InductionThe Mono And/Or Diubiquitination Form Increases And Forms Filamentous Structures That Colocalize With Krt8 And Krt18 Intermediate Filament Network In Simple Epithelial Cells |
| Alternative Antibody Names | Anti-Death Effector Domain-Containing Protein antibodyAnti-Dedpro1 antibodyAnti-Death Effector Domain-Containing Testicular Molecule antibodyAnti-Flded-1 antibodyAnti-DEDD antibodyAnti-DEDPRO1 antibodyAnti-DEFT antibodyAnti-KE05 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
