| Post Translational Modifications | May be phosphorylated by DNA-PK complex in a DNA independent manner (in vitro). |
| Function | Transcription factor that binds to sequence with multiple copies of 5'-TTCCGG-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. |
| Protein Name | Deformed Epidermal Autoregulatory Factor 1 HomologNuclear Deaf-1-Related Transcriptional RegulatorNudrSuppressinZinc Finger Mynd Domain-Containing Protein 5 |
| Cellular Localisation | Isoform 1: NucleusCytoplasmCytoplasmic In Non-Mucinous Colorectal CarcinomaWhen Expressed AloneLocalized Almost Exclusively In The Nucleus ButWhen Expressed With Isoform 4Nuclear Expression Decreases To 32% And Cytoplasmic Expression Increases By 270%Isoform 2: SecretedSecreted In Some Cell TypesIsoform 3: SecretedIsoform 4: CytoplasmNucleusLocalizes Mainly In The Cytoplasm ButWhen Expressed With Isoform 1Nuclear Localization Is Enhanced |
| Alternative Antibody Names | Anti-Deformed Epidermal Autoregulatory Factor 1 Homolog antibodyAnti-Nuclear Deaf-1-Related Transcriptional Regulator antibodyAnti-Nudr antibodyAnti-Suppressin antibodyAnti-Zinc Finger Mynd Domain-Containing Protein 5 antibodyAnti-DEAF1 antibodyAnti-SPN antibodyAnti-ZMYND5 antibody |
Information sourced from Uniprot.org
