| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Dynactin subunit 3 (117-167 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DCTN3 |
| Gene ID: | 11258 |
| Uniprot ID: | DCTN3_HUMAN |
| Immunogen Region: | 117-167 aa |
| Specificity: | This antibody detects endogenous levels of DCTN3 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human DCTN3 at the amino acid range 117-167 |
| Function | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Together with dynein may be involved in spindle assembly and cytokinesis. |
| Protein Name | Dynactin Subunit 3Dynactin Complex Subunit 22 Kda SubunitP22 |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-2565942Reactome: R-HSA-3371497Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-6807878Reactome: R-HSA-6811436Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeChromosomeCentromereKinetochoreSpindleCleavage FurrowMidbodyLocalizes To Punctate Cytoplasmic Structures And To The Centrosome During InterphaseAnd To Kinetochores And To Spindle Poles Throughout MitosisColocalizes With Dynein To The Cleavage Furrow And To Midbody Of Dividing Cells |
| Alternative Antibody Names | Anti-Dynactin Subunit 3 antibodyAnti-Dynactin Complex Subunit 22 Kda Subunit antibodyAnti-P22 antibodyAnti-DCTN3 antibodyAnti-DCTN22 antibody |
Information sourced from Uniprot.org