Anti-DCP1A antibody [R97-2Z-7] (STJA0035480)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human DCP1A
General Information
| Short Description | Rabbit monoclonal anti-DCP1A for use in WB, IHC-P, ICC, IF and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R97-2Z-7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:100-1:200IF 1:50-1:200FC 1:50 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | DCP1A |
| Gene ID | 55802 |
| Uniprot ID | DCP1A_HUMAN |
| Immunogen | A synthesized peptide derived from human DCP1A |
Additional Info
| Tissue Specificity | Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas. |
| Function | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Essential for embryonic development. |
| Protein Name | Mrna-Decapping Enzyme 1aSmad4-Interacting Transcriptional Co-ActivatorTranscription Factor Smif |
| Database Links | Reactome: R-HSA-430039Reactome: R-HSA-450385Reactome: R-HSA-450513Reactome: R-HSA-975957 |
| Cellular Localisation | CytoplasmP-BodyNucleusCo-Localizes With Nanos3 In The Processing BodiesPredominantly CytoplasmicIn Processing Bodies (Pb)NuclearAfter Tgfb1 TreatmentTranslocation To The Nucleus Depends On Interaction With Smad4 |
| Alternative Antibody Names | Anti-Mrna-Decapping Enzyme 1a antibodyAnti-Smad4-Interacting Transcriptional Co-Activator antibodyAnti-Transcription Factor Smif antibodyAnti-DCP1A antibodyAnti-SMIF antibody |
Information sourced from Uniprot.org