Anti-DCP1A antibody (303-582) (STJ29513)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DCP1A (303-582) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DCP1A |
| Gene ID | 55802 |
| Uniprot ID | DCP1A_HUMAN |
| Immunogen Region | 303-582 |
| Immunogen Sequence | NEKHAPTYTIPLSPVLSPTL PAEAPTAQVPPSLPRNSTMM QAVKTTPRQRSPLLNQPVPE LSHASLIANQSPFRAPLNVT NTAGTSLPSVDLLQKLRLTP QHDQIQTQPLGKGAMVASFS PAAGQLATPESFIEPPSKTA AARVAASASLSNMVLAPLQS MQQNQDPEVFVQPKVLSSAI PVAGAPLVTATTTAVSSVLL APSVFQQTVTRSSDLERKAS SPSPLTIGTPESQRKPSII |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 303-582 of human DCP1A (NP_060873.4). |
Additional Info
| Tissue Specificity | Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas. |
| Function | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Essential for embryonic development. |
| Protein Name | Mrna-Decapping Enzyme 1aSmad4-Interacting Transcriptional Co-ActivatorTranscription Factor Smif |
| Database Links | Reactome: R-HSA-430039Reactome: R-HSA-450385Reactome: R-HSA-450513Reactome: R-HSA-975957 |
| Cellular Localisation | CytoplasmP-BodyNucleusCo-Localizes With Nanos3 In The Processing BodiesPredominantly CytoplasmicIn Processing Bodies (Pb)NuclearAfter Tgfb1 TreatmentTranslocation To The Nucleus Depends On Interaction With Smad4 |
| Alternative Antibody Names | Anti-Mrna-Decapping Enzyme 1a antibodyAnti-Smad4-Interacting Transcriptional Co-Activator antibodyAnti-Transcription Factor Smif antibodyAnti-DCP1A antibodyAnti-SMIF antibody |
Information sourced from Uniprot.org