• Immunohistochemistry analysis of paraffin-embedded human liver using DBH antibody (STJ115906) at dilution of 1:200 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.

Anti-DBH antibody (388-617) (STJ115906)

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STJ115906

£112.50 - £522.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DBH (388-617) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DBH
Gene ID: 1621
Uniprot ID: DOPO_HUMAN
Immunogen Region: 388-617
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 388-617 of human DBH (NP_000778.3).
Immunogen Sequence: GYCTDKCTQLALPPSGIHIF ASQLHTHLTGRKVVTVLVRD GREWEIVNQDNHYSPHFQEI RMLKKVVSVHPGDVLITSCT YNTEDRELATVGGFGILEEM CVNYVHYYPQTQLELCKSAV DAGFLQKYFHLINRFNNEDV CTCPQASVSQQFTSVPWNSF NRDVLKALYSFAPISMHCNK SSAVRFQGEWNLQPLPKVIS TLEEPTPQCPTSQGRSPAGP TVVSIGGGKG
Post Translational Modifications N-glycosylated. Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form.
Function Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters.
Protein Name Dopamine Beta-Hydroxylase
Dopamine Beta-Monooxygenase Cleaved Into - Soluble Dopamine Beta-Hydroxylase
Database Links Reactome: R-HSA-209905
Cellular Localisation Soluble Dopamine Beta-Hydroxylase: Cytoplasmic Vesicle
Secretory Vesicle Lumen
Cytoplasmic Vesicle
Secretory Vesicle
Chromaffin Granule Lumen
Secreted
Secretory Vesicle Membrane
Single-Pass Type Ii Membrane Protein
Chromaffin Granule Membrane
Alternative Antibody Names Anti-Dopamine Beta-Hydroxylase antibody
Anti-Dopamine Beta-Monooxygenase Cleaved Into - Soluble Dopamine Beta-Hydroxylase antibody
Anti-DBH antibody

Information sourced from Uniprot.org

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