| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
DAGLB |
| Gene ID: |
221955 |
| Uniprot ID: |
DGLB_HUMAN |
| Immunogen Region: |
200-400 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-400 of human DAGLB (NP_631918.3). |
| Immunogen Sequence: |
LCCCIGKDDHTRVAFSSTAE LFSTYFSDTDLVPSDIAAGL ALLHQQQDNIRNNQEPAQVV CHAPGSSQEADLDAELENCH HYMQFAAAAYGWPLYIYRNP LTGLCRIGGDCCRSRTTDYD LVGGDQLNCHFGSILHTTGL QYRDFIHVSFHDKVYELPFL VALDHRKESVVVAVRGTMSL QDVLTDLSAESEVLDVECEV Q |
| Function | Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production. Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages. |
| Protein Name | Diacylglycerol Lipase-BetaDagl-BetaDgl-BetaKccr13lPufa-Specific Triacylglycerol LipaseSn1-Specific Diacylglycerol Lipase Beta |
| Database Links | Reactome: R-HSA-426048 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Diacylglycerol Lipase-Beta antibodyAnti-Dagl-Beta antibodyAnti-Dgl-Beta antibodyAnti-Kccr13l antibodyAnti-Pufa-Specific Triacylglycerol Lipase antibodyAnti-Sn1-Specific Diacylglycerol Lipase Beta antibodyAnti-DAGLB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
