| Function | Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production. Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages. |
| Protein Name | Diacylglycerol Lipase-BetaDagl-BetaDgl-BetaKccr13lPufa-Specific Triacylglycerol LipaseSn1-Specific Diacylglycerol Lipase Beta |
| Database Links | Reactome: R-HSA-426048 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Diacylglycerol Lipase-Beta antibodyAnti-Dagl-Beta antibodyAnti-Dgl-Beta antibodyAnti-Kccr13l antibodyAnti-Pufa-Specific Triacylglycerol Lipase antibodyAnti-Sn1-Specific Diacylglycerol Lipase Beta antibodyAnti-DAGLB antibody |
Information sourced from Uniprot.org
