| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Diacylglycerol lipase-alpha (900-980 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DAGLA |
| Gene ID: |
747 |
| Uniprot ID: |
DGLA_HUMAN |
| Immunogen Region: |
900-980 aa |
| Specificity: |
DGLA Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 900-980 |
| Post Translational Modifications | Phosphorylated at Ser-782 and Ser-808 by CAMK2A.phosphorylation by CAMK2A inhibits diacylglycerol lipase activity. |
| Function | Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG. Has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation. |
| Protein Name | Diacylglycerol Lipase-AlphaDagl-AlphaDgl-AlphaNeural Stem Cell-Derived Dendrite RegulatorSn1-Specific Diacylglycerol Lipase Alpha |
| Database Links | Reactome: R-HSA-426048 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Density MembraneEarly Endosome MembraneCell ProjectionDendritic Spine MembraneCycles Between The Cell Surface And An Intracellular Endosomal CompartmentInternalized By Early Endosomes Via A Clathrin-Independent Pathway Before Transport Back To The Postsynaptic Membrane Surface In A Pkc-Dependent Manner |
| Alternative Antibody Names | Anti-Diacylglycerol Lipase-Alpha antibodyAnti-Dagl-Alpha antibodyAnti-Dgl-Alpha antibodyAnti-Neural Stem Cell-Derived Dendrite Regulator antibodyAnti-Sn1-Specific Diacylglycerol Lipase Alpha antibodyAnti-DAGLA antibodyAnti-C11orf11 antibodyAnti-KIAA0659 antibodyAnti-NSDDR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
