| Post Translational Modifications | Phosphorylated at Ser-782 and Ser-808 by CAMK2A.phosphorylation by CAMK2A inhibits diacylglycerol lipase activity. |
| Function | Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG. Has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation. |
| Protein Name | Diacylglycerol Lipase-AlphaDagl-AlphaDgl-AlphaNeural Stem Cell-Derived Dendrite RegulatorSn1-Specific Diacylglycerol Lipase Alpha |
| Database Links | Reactome: R-HSA-426048 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Density MembraneEarly Endosome MembraneCell ProjectionDendritic Spine MembraneCycles Between The Cell Surface And An Intracellular Endosomal CompartmentInternalized By Early Endosomes Via A Clathrin-Independent Pathway Before Transport Back To The Postsynaptic Membrane Surface In A Pkc-Dependent Manner |
| Alternative Antibody Names | Anti-Diacylglycerol Lipase-Alpha antibodyAnti-Dagl-Alpha antibodyAnti-Dgl-Alpha antibodyAnti-Neural Stem Cell-Derived Dendrite Regulator antibodyAnti-Sn1-Specific Diacylglycerol Lipase Alpha antibodyAnti-DAGLA antibodyAnti-C11orf11 antibodyAnti-KIAA0659 antibodyAnti-NSDDR antibody |
Information sourced from Uniprot.org
