Anti-Dachshund homolog 1 antibody (Internal) (STJ71512)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Dachshund homolog 1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 75 and 52kDa bands observed in Human Kidney lysates (calculated MW of 73.0kDa according to NP_542937.1 and of 51.9kDa according to NP_004383.2). Recommended concentration: 0.1-0 |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | DACH1 |
| Gene ID | 1602 |
| Uniprot ID | DACH1_HUMAN |
| Accession Number | NP_542937.1; NP_542938.1; NP_004383.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | SPVENTPQNNECK |
| Specificity | This antibody is expected to recognise all three reported isoforms (NP_542937.1; NP_542938.1; NP_004383.2). |
Additional Info
| Function | Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain. |
| Protein Name | Dachshund Homolog 1Dach1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dachshund Homolog 1 antibodyAnti-Dach1 antibodyAnti-DACH1 antibodyAnti-DACH antibody |
Information sourced from Uniprot.org