| Tissue Specificity | Expressed in all tissues examined. |
| Function | Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Together with DAAM2, required for myocardial maturation and sarcomere assembly. During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation. |
| Protein Name | Disheveled-Associated Activator Of Morphogenesis 1 |
| Database Links | Reactome: R-HSA-4086400Reactome: R-HSA-5663220Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148 |
| Cellular Localisation | CytoplasmCytoskeletonCilium Basal BodyPerinuclearColocalizes With Rhoa And Kank1 Around Centrosomes |
| Alternative Antibody Names | Anti-Disheveled-Associated Activator Of Morphogenesis 1 antibodyAnti-DAAM1 antibodyAnti-KIAA0666 antibody |
Information sourced from Uniprot.org
