• Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:200
  • Western blot analysis of HEPG2 cells using Antibody diluted at 1000. Secondary antibody was diluted at 1:20000

Anti-Cytokeratin 14/17 antibody (261-310 aa) (STJ98650)

SKU:
STJ98650

£48.00 - £252.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Keratin, type I cytoskeletal 14 and Keratin, type I cytoskeletal 17 (261-310 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:10000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KRT14
KRT17
Gene ID: 3861
3872
Uniprot ID: K1C14_HUMAN
K1C17_HUMAN
Immunogen Region: 261-310 aa
Specificity: The antibody detects endogenous Cytokeratin 14/17 protein
Immunogen: Synthetic peptide from the human protein at the amino acid range 261-310
Post Translational Modifications A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus. Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex.
Function The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
Protein Name Keratin - Type I Cytoskeletal 14
Cytokeratin-14
Ck-14
Keratin-14
K14
Database Links Reactome: R-HSA-446107
Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Cellular Localisation Cytoplasm
Nucleus
Expressed In Both As A Filamentous Pattern
Alternative Antibody Names Anti-Keratin - Type I Cytoskeletal 14 antibody
Anti-Cytokeratin-14 antibody
Anti-Ck-14 antibody
Anti-Keratin-14 antibody
Anti-K14 antibody
Anti-KRT14 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance