| Tissue Specificity | Expressed in most fetal and adult tissues with highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain. Expressed at high levels in lung, pancreas, skin and uterus (at protein level). Lower expression level is detected in spleen, kidney, intestine and adipose tissue (at protein level). |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals. RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling. Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA. Able to metabolize other RAs such as 9-cis, 13-cis and 9,13-di-cis RA. Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA. May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid. |
| Protein Name | Cytochrome P450 26a1Cyp26a1Cytochrome P450 Retinoic Acid-Inactivating 1Cytochrome P450raiHp450raiRetinoic Acid 4-HydroxylaseRetinoic Acid-Metabolizing Cytochrome |
| Database Links | Reactome: R-HSA-211916Reactome: R-HSA-5365859 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 26a1 antibodyAnti-Cyp26a1 antibodyAnti-Cytochrome P450 Retinoic Acid-Inactivating 1 antibodyAnti-Cytochrome P450rai antibodyAnti-Hp450rai antibodyAnti-Retinoic Acid 4-Hydroxylase antibodyAnti-Retinoic Acid-Metabolizing Cytochrome antibodyAnti-CYP26A1 antibodyAnti-CYP26 antibodyAnti-P450RAI1 antibody |
Information sourced from Uniprot.org
