| Function | A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid. With initial hydroxylation at C-23 (via C23-oxidation pathway), catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end product. Preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin. |
| Protein Name | 1 -25-Dihydroxyvitamin D(3 24-Hydroxylase - Mitochondrial24-OhaseVitamin D(3 24-HydroxylaseCytochrome P450 24a1Cytochrome P450-Cc24 |
| Database Links | Reactome: R-HSA-196791Reactome: R-HSA-211916Reactome: R-HSA-5579010 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-1 -25-Dihydroxyvitamin D(3 24-Hydroxylase - Mitochondrial antibodyAnti-24-Ohase antibodyAnti-Vitamin D(3 24-Hydroxylase antibodyAnti-Cytochrome P450 24a1 antibodyAnti-Cytochrome P450-Cc24 antibodyAnti-CYP24A1 antibodyAnti-CYP24 antibody |
Information sourced from Uniprot.org
