| Function | Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. |
| Protein Name | Ccn Family Member 1Cellular Communication Network Factor 1Cysteine-Rich Angiogenic Inducer 61Insulin-Like Growth Factor-Binding Protein 10Ibp-10Igf-Binding Protein 10Igfbp-10Protein Cyr61Protein Gig1 |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Ccn Family Member 1 antibodyAnti-Cellular Communication Network Factor 1 antibodyAnti-Cysteine-Rich Angiogenic Inducer 61 antibodyAnti-Insulin-Like Growth Factor-Binding Protein 10 antibodyAnti-Ibp-10 antibodyAnti-Igf-Binding Protein 10 antibodyAnti-Igfbp-10 antibodyAnti-Protein Cyr61 antibodyAnti-Protein Gig1 antibodyAnti-CCN1 antibodyAnti-CYR61 antibodyAnti-GIG1 antibodyAnti-IGFBP10 antibody |
Information sourced from Uniprot.org
