| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cytochrome P450 4F2 20-monooxygenase 1 omega-hydroxylase 1 (41-90 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CYP4F2 |
| Gene ID: | 8529 |
| Uniprot ID: | CP4F2_HUMAN |
| Immunogen Region: | 41-90 aa |
| Specificity: | CYP4F2 Polyclonal Antibody detects endogenous levels of CYP4F2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CYP4F2 at the amino acid range 41-90 |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure. Plays a role in the oxidative inactivation of eicosanoids, including both pro-inflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs. Catalyzes omega-hydroxylation of 3-hydroxy fatty acids. Converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolites. Contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shortening. Plays an important role in vitamin metabolism by chain shortening. Catalyzes omega-hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherols, thus promoting retention of alpha-tocopherols in tissues. Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation. |
| Protein Name | Cytochrome P450 4f2 20-Hydroxyeicosatetraenoic Acid Synthase 20-Hete Synthase Arachidonic Acid Omega-Hydroxylase Cypivf2 Cytochrome P450-Ltb-Omega Docosahexaenoic Acid Omega-Hydroxylase Leukotriene-B(4 20-Monooxygenase 1 Leukotriene-B(4 Omega-Hydroxylase 1 Phylloquinone Omega-Hydroxylase Cyp4f2 |
| Database Links | Reactome: R-HSA-211935 Reactome: R-HSA-211958 Reactome: R-HSA-211979 Reactome: R-HSA-2142691 Reactome: R-HSA-2142816 |
| Cellular Localisation | Microsome Membrane Peripheral Membrane Protein Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 4f2 antibody Anti-20-Hydroxyeicosatetraenoic Acid Synthase antibody Anti-20-Hete Synthase antibody Anti-Arachidonic Acid Omega-Hydroxylase antibody Anti-Cypivf2 antibody Anti-Cytochrome P450-Ltb-Omega antibody Anti-Docosahexaenoic Acid Omega-Hydroxylase antibody Anti-Leukotriene-B(4 20-Monooxygenase 1 antibody Anti-Leukotriene-B(4 Omega-Hydroxylase 1 antibody Anti-Phylloquinone Omega-Hydroxylase Cyp4f2 antibody Anti-CYP4F2 antibody |
Information sourced from Uniprot.org