| Post Translational Modifications | 4-hydroxynonenal conjugation impairs substrate binding and the long-chain fatty acid omega-monooxygenase activity. |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids. Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation. Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE). Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil. Catalyzes the oxidation of dialkylresorcinol 2. |
| Protein Name | Cytochrome P450 4f11Cypivf113-Hydroxy Fatty Acids Omega-Hydroxylase Cyp4f11Docosahexaenoic Acid Omega-HydroxylaseLong-Chain Fatty Acid Omega-MonooxygenasePhylloquinone Omega-Hydroxylase Cyp4f11 |
| Database Links | Reactome: R-HSA-211935Reactome: R-HSA-211958Reactome: R-HSA-211979Reactome: R-HSA-2142691 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 4f11 antibodyAnti-Cypivf11 antibodyAnti-3-Hydroxy Fatty Acids Omega-Hydroxylase Cyp4f11 antibodyAnti-Docosahexaenoic Acid Omega-Hydroxylase antibodyAnti-Long-Chain Fatty Acid Omega-Monooxygenase antibodyAnti-Phylloquinone Omega-Hydroxylase Cyp4f11 antibodyAnti-CYP4F11 antibody |
Information sourced from Uniprot.org
