| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-24-hydroxycholesterol 7-alpha-hydroxylase (361-410 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CYP39A1 |
| Gene ID: | 51302 |
| Uniprot ID: | CP39A_HUMAN |
| Immunogen Region: | 361-410 aa |
| Specificity: | CYP39A1 Polyclonal Antibody detects endogenous levels of CYP39A1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Cytochrome P450 39A1 at the amino acid range 361-410 |
| Function | A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). |
| Protein Name | 24-Hydroxycholesterol 7-Alpha-HydroxylaseCytochrome P450 39a1Hcyp39a1Oxysterol 7-Alpha-Hydroxylase |
| Database Links | Reactome: R-HSA-193775Reactome: R-HSA-211976 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-24-Hydroxycholesterol 7-Alpha-Hydroxylase antibodyAnti-Cytochrome P450 39a1 antibodyAnti-Hcyp39a1 antibodyAnti-Oxysterol 7-Alpha-Hydroxylase antibodyAnti-CYP39A1 antibody |
Information sourced from Uniprot.org
