| Function | A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin. |
| Protein Name | Cytochrome P450 2u1Long-Chain Fatty Acid Omega-Monooxygenase |
| Database Links | Reactome: R-HSA-211958Reactome: R-HSA-2142816Reactome: R-HSA-5579011 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMicrosome MembraneMitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2u1 antibodyAnti-Long-Chain Fatty Acid Omega-Monooxygenase antibodyAnti-CYP2U1 antibody |
Information sourced from Uniprot.org
