Anti-CYP2U1 antibody (281-330 aa) (STJ92589)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Cytochrome P450 2U1 at the amino acid range 281-330
General Information
| Short Description | Rabbit polyclonal anti-Cytochrome P450 2U1 (281-330 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CYP2U1 |
| Gene ID | 113612 |
| Uniprot ID | CP2U1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Cytochrome P450 2U1 at the amino acid range 281-330 |
| Immunogen Region | 281-330 aa |
| Specificity | CYP2U1 Polyclonal Antibody detects endogenous levels of CYP2U1 protein. |
Additional Info
| Function | A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin. |
| Protein Name | Cytochrome P450 2u1Long-Chain Fatty Acid Omega-Monooxygenase |
| Database Links | Reactome: R-HSA-211958Reactome: R-HSA-2142816Reactome: R-HSA-5579011 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMicrosome MembraneMitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2u1 antibodyAnti-Long-Chain Fatty Acid Omega-Monooxygenase antibodyAnti-CYP2U1 antibody |
Information sourced from Uniprot.org