| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CYP2F1 |
| Gene ID: | 1572 |
| Uniprot ID: | CP2F1_HUMAN |
| Immunogen Region: | 100-290 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-290 of human CYP2F1 (NP_000765.2). |
| Immunogen Sequence: | DYPAFFNFTKGNGIAFSSGD RWKVLRQFSIQILRNFGMGK RSIEERILEEGSFLLAELRK TEGEPFDPTFVLSRSVSNII CSVLFGSRFDYDDERLLTII RLINDNFQIMSSPWGELYDI FPSLLDWVPGPHQRIFQNFK CLRDLIAHSVHDHQASLDPR SPRDFIQCFLTKMAEEKEDP LSHFHMDTLLM |
| Tissue Specificity | Expressed in lung. Rarely detected in liver and placenta. |
| Function | May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. |
| Protein Name | Cytochrome P450 2f1Cypiif1 |
| Database Links | Reactome: R-HSA-211935Reactome: R-HSA-211981Reactome: R-HSA-211999 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2f1 antibodyAnti-Cypiif1 antibodyAnti-CYP2F1 antibody |
Information sourced from Uniprot.org