| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYP2C9 (211-490) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP2C9 |
| Gene ID: |
1559 |
| Uniprot ID: |
CP2C9_HUMAN |
| Immunogen Region: |
211-490 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 211-490 of human CYP2C9 (NP_000762.2). |
| Immunogen Sequence: |
PWIQICNNFSPIIDYFPGTH NKLLKNVAFMKSYILEKVKE HQESMDMNNPQDFIDCFLMK MEKEKHNQPSEFTIESLENT AVDLFGAGTETTSTTLRYAL LLLLKHPEVTAKVQEEIERV IGRNRSPCMQDRSHMPYTDA VVHEVQRYIDLLPTSLPHAV TCDIKFRNYLIPKGTTILIS LTSVLHDNKEFPNPEMFDPH HFLDEGGNFKKSKYFMPFSA GKRICVGEALAGMELFLFL |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2. Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol. Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan. |
| Protein Name | Cytochrome P450 2c9(R-Limonene 6-Monooxygenase(S-Limonene 6-Monooxygenase(S-Limonene 7-MonooxygenaseCypiic9Cholesterol 25-HydroxylaseCytochrome P-450mpCytochrome P450 Mp-4Cytochrome P450 Mp-8Cytochrome P450 Pb-1S-Mephenytoin 4-Hydroxylase |
| Database Links | Reactome: R-HSA-211981Reactome: R-HSA-211999Reactome: R-HSA-2142670Reactome: R-HSA-2142816Reactome: R-HSA-9027307Reactome: R-HSA-9749641 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2c9 antibodyAnti-(R-Limonene 6-Monooxygenase antibodyAnti-(S-Limonene 6-Monooxygenase antibodyAnti-(S-Limonene 7-Monooxygenase antibodyAnti-Cypiic9 antibodyAnti-Cholesterol 25-Hydroxylase antibodyAnti-Cytochrome P-450mp antibodyAnti-Cytochrome P450 Mp-4 antibodyAnti-Cytochrome P450 Mp-8 antibodyAnti-Cytochrome P450 Pb-1 antibodyAnti-S-Mephenytoin 4-Hydroxylase antibodyAnti-CYP2C9 antibodyAnti-CYP2C10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
