Anti-CYP2B6 antibody (247-259) (STJ73449)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CYP2B6 (247-259) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 75kDa band observed in lysates of cell line HepG2 and K562 (calculated MW of 56.3kDa according to NP_000758.1). Recommended concentration: 0.1-0.3ยตg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CYP2B6 |
| Gene ID | 1555 |
| Uniprot ID | CP2B6_HUMAN |
| Accession Number | NP_000758.1 |
| Immunogen Region | 247-259 |
| Immunogen Sequence | HSVEKHRETLDPS |
Additional Info
| Post Translational Modifications | Phosphorylation is accompanied by a decrease in enzyme activity. |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2. Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs. Acts as a 1,4-cineole 2-exo-monooxygenase. Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs. |
| Protein Name | Cytochrome P450 2b61 -4-Cineole 2-Exo-MonooxygenaseCypiib6Cytochrome P450 Iib1 |
| Database Links | Reactome: R-HSA-211935Reactome: R-HSA-211945Reactome: R-HSA-211981Reactome: R-HSA-211999 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2b6 antibodyAnti-1 -4-Cineole 2-Exo-Monooxygenase antibodyAnti-Cypiib6 antibodyAnti-Cytochrome P450 Iib1 antibodyAnti-CYP2B6 antibody |
Information sourced from Uniprot.org