| Function | A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). |
| Protein Name | Steroid 21-Hydroxylase21-OhaseCytochrome P-450c21Cytochrome P450 21Cytochrome P450 XxiCytochrome P450-C21Cytochrome P450-C21b |
| Database Links | Reactome: R-HSA-193993Reactome: R-HSA-194002Reactome: R-HSA-211976Reactome: R-HSA-5579021 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Steroid 21-Hydroxylase antibodyAnti-21-Ohase antibodyAnti-Cytochrome P-450c21 antibodyAnti-Cytochrome P450 21 antibodyAnti-Cytochrome P450 Xxi antibodyAnti-Cytochrome P450-C21 antibodyAnti-Cytochrome P450-C21b antibodyAnti-CYP21A2 antibodyAnti-CYP21 antibodyAnti-CYP21B antibody |
Information sourced from Uniprot.org
