| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CYP21A2 |
| Gene ID: |
1589 |
| Uniprot ID: |
CP21A_HUMAN |
| Immunogen Region: |
361-495 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 361-495 of human CYP21A2 (NP_000491.4). |
| Immunogen Sequence: |
PLALPHRTTRPSSISGYDIP EGTVIIPNLQGAHLDETVWE RPHEFWPDRFLEPGKNSRAL AFGCGARVCLGEPLARLELF VVLTRLLQAFTLLPSGDALP SLQPLPHCSVILKMQPFQVR LQPRGMGAHSPGQSQ |
| Function | A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). |
| Protein Name | Steroid 21-Hydroxylase21-OhaseCytochrome P-450c21Cytochrome P450 21Cytochrome P450 XxiCytochrome P450-C21Cytochrome P450-C21b |
| Database Links | Reactome: R-HSA-193993Reactome: R-HSA-194002Reactome: R-HSA-211976Reactome: R-HSA-5579021 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Steroid 21-Hydroxylase antibodyAnti-21-Ohase antibodyAnti-Cytochrome P-450c21 antibodyAnti-Cytochrome P450 21 antibodyAnti-Cytochrome P450 Xxi antibodyAnti-Cytochrome P450-C21 antibodyAnti-Cytochrome P450-C21b antibodyAnti-CYP21A2 antibodyAnti-CYP21 antibodyAnti-CYP21B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
