| Host: | Mouse |
| Applications: | ELISA/SPR |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Cytochrome C-Somatic is suitable for use in ELISA and SPR research applications. |
| Clonality : | Monoclonal |
| Clone ID : | SAA1417 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2ak |
| Formulation: | 0.01M PBS, pH 7.4, 0.09% Sodium azide. |
| Purification: | Protein A/G purified from cell culture supernatant. |
| Concentration: | 1 mg/ml |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Post Translational Modifications | Binds 1 heme c group covalently per subunit. Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration. |
| Function | Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. |
| Protein Name | Cytochrome C - Somatic |
| Database Links | Reactome: R-MMU-111457Reactome: -MMU-111458Reactome: -MMU-111459Reactome: -MMU-2151201Reactome: -MMU-3299685Reactome: -MMU-5620971Reactome: -MMU-5628897Reactome: -MMU-611105Reactome: -MMU-9627069Reactome: -MMU-9707564 |
| Cellular Localisation | Mitochondrion Intermembrane SpaceLoosely Associated With The Inner Membrane |
| Alternative Antibody Names | Anti-Cytochrome C - Somatic antibodyAnti-Cycs antibody |
Information sourced from Uniprot.org
