Anti-Cyclophilin A antibody [SM0429] (STJA0010429)

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STJA0010429
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Host: Mouse
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Cyclophilin A is suitable for use in Western Blot research applications.
Clonality : Monoclonal
Clone ID : SM0429
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: PBS with 0.15% ProClin300, 100 Mu g/mL BSA and 50% glycerol.
Purification: Affinity purification
Dilution Range: WB (H, M, R) 1:500-1:1000
Storage Instruction: Store at-20C for up to one year, and avoid repeated freeze-thaw cycles.
Gene Symbol: Ppia
Gene ID: 268373
Uniprot ID: PPIA_MOUSE
Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Cyclophilin A
Post Translational Modifications Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition. Acetylation at Lys-125 favors the interaction with TARDBP.
Function Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation. Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1. Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis. In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2. Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1. Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates. Plays an important role in platelet activation and aggregation. Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton. Binds heparan sulfate glycosaminoglycans.
Protein Name Peptidyl-Prolyl Cis-Trans Isomerase A
Ppiase A
Cyclophilin A
Cyclosporin A-Binding Protein
Rotamase A
Sp18 Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase A - N-Terminally Processed
Database Links Reactome: R-MMU-210991
Reactome: -MMU-6798695
Cellular Localisation Cytoplasm
Secreted
Nucleus
Secretion Occurs In Response To Oxidative Stress In Vascular Smooth Muscle Through A Vesicular Secretory Pathway That Involves Actin Remodeling And Myosin Ii Activation
And Mediates Erk1/2 Activation
Alternative Antibody Names Anti-Peptidyl-Prolyl Cis-Trans Isomerase A antibody
Anti-Ppiase A antibody
Anti-Cyclophilin A antibody
Anti-Cyclosporin A-Binding Protein antibody
Anti-Rotamase A antibody
Anti-Sp18 Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase A - N-Terminally Processed antibody
Anti-Ppia antibody

Information sourced from Uniprot.org