| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | CCNE1 |
| Gene ID: | 898 |
| Uniprot ID: | CCNE1_HUMAN |
| Immunogen Region: | 300-410 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-410 of human Cyclin E1 (NP_001229.1). |
| Immunogen Sequence: | AASALYHFSSSELMQKVSGY QWCDIENCVKWMVPFAMVIR ETGSSKLKHFRGVADEDAHN IQTHRDSLDLLDKARAKKAM LSEQNRASPLPSGLLTPPQS GKKQSSGPEMA |
| Tissue Specificity | Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. |
| Post Translational Modifications | Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7. Ubiquitinated by UHRF2.appears to occur independently of phosphorylation. |
| Function | Essential for the control of the cell cycle at the G1/S (start) transition. |
| Protein Name | G1/S-Specific Cyclin-E1 |
| Database Links | Reactome: R-HSA-1538133Reactome: R-HSA-187577Reactome: R-HSA-2559586Reactome: R-HSA-390471Reactome: R-HSA-6804116Reactome: R-HSA-69017Reactome: R-HSA-69200Reactome: R-HSA-69202Reactome: R-HSA-69205Reactome: R-HSA-69231Reactome: R-HSA-69563Reactome: R-HSA-8849470Reactome: R-HSA-9661069Reactome: R-HSA-9706019 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-G1/S-Specific Cyclin-E1 antibodyAnti-CCNE1 antibodyAnti-CCNE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
