| Short Description : | Mouse monoclonal anti-Cyclin B1 for use in IHC-P in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-P |
| Host: | Mouse |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | 1B3-3B1-1B4 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | Affinity Purified |
| Dilution Range: | IHC 1:50-1:100 |
| Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | CCNB1 |
| Gene ID: | 891 |
| Uniprot ID: | CCNB1_HUMAN |
| Immunogen: | Synthetic peptide conjugated to KLH. |
| Post Translational Modifications | Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Deubiquitinated by USP22 during G2/M phase. Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site. |
| Function | Essential for the control of the cell cycle at the G2/M (mitosis) transition. |
| Protein Name | G2/Mitotic-Specific Cyclin-B1 |
| Database Links | Reactome: R-HSA-113507Reactome: R-HSA-156711Reactome: R-HSA-162658Reactome: R-HSA-174048Reactome: R-HSA-176408Reactome: R-HSA-176412Reactome: R-HSA-176417Reactome: R-HSA-2299718Reactome: R-HSA-2465910Reactome: R-HSA-2500257Reactome: R-HSA-2514853Reactome: R-HSA-2565942Reactome: R-HSA-2980767Reactome: R-HSA-2995383Reactome: R-HSA-3301854Reactome: R-HSA-4419969Reactome: R-HSA-6804114Reactome: R-HSA-68875Reactome: R-HSA-69273Reactome: R-HSA-69478Reactome: R-HSA-75035Reactome: R-HSA-8852276Reactome: R-HSA-8878166Reactome: R-HSA-9725371Reactome: R-HSA-9825892 |
| Cellular Localisation | CytoplasmNucleusCytoskeletonMicrotubule Organizing CenterCentrosome |
| Alternative Antibody Names | Anti-G2/Mitotic-Specific Cyclin-B1 antibodyAnti-CCNB1 antibodyAnti-CCNB antibody |
Information sourced from Uniprot.org
