Anti-CYBB/NOX2 antibody [SAA0847] (STJA0027712)

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STJA0027712
€318.13 - €473.13
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Host: Mouse
Applications: FC/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Cytochrome B-245 Heavy Chain is suitable for use in Flow Cytometry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : SAA0847
Conjugation: Unconjugated
Isotype: IgG2ak
Formulation: 0.01M PBS, pH 7.4, 0.09% Sodium azide.
Purification: Protein A/G purified from cell culture supernatant.
Concentration: 1 mg/ml
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: CYBB
Gene ID: 1536
Uniprot ID: CY24B_HUMAN
Post Translational Modifications Glycosylated. Phosphorylated on Ser and Thr residues. Undergoes 'Lys-48'-linked polyubiquitination, likely by RNF145, triggering endoplasmic reticulum-associated degradation.
Function Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Protein Name Cytochrome B-245 Heavy Chain
Cgd91-Phox
Cytochrome B(558 Subunit Beta
Cytochrome B558 Subunit Beta
Heme-Binding Membrane Glycoprotein Gp91phox
Nadph Oxidase 2
Neutrophil Cytochrome B 91 Kda Polypeptide
Superoxide-Generating Nadph Oxidase Heavy Chain Subunit
Gp91-1
Gp91-Phox
P22 Phagocyte B-Cytochrome
Database Links Reactome: R-HSA-1222556
Reactome: R-HSA-1236973
Reactome: R-HSA-3299685
Reactome: R-HSA-4420097
Reactome: R-HSA-5668599
Reactome: R-HSA-6798695
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013423
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
As Unassembled Monomer May Localize To The Endoplasmic Reticulum
Alternative Antibody Names Anti-Cytochrome B-245 Heavy Chain antibody
Anti-Cgd91-Phox antibody
Anti-Cytochrome B(558 Subunit Beta antibody
Anti-Cytochrome B558 Subunit Beta antibody
Anti-Heme-Binding Membrane Glycoprotein Gp91phox antibody
Anti-Nadph Oxidase 2 antibody
Anti-Neutrophil Cytochrome B 91 Kda Polypeptide antibody
Anti-Superoxide-Generating Nadph Oxidase Heavy Chain Subunit antibody
Anti-Gp91-1 antibody
Anti-Gp91-Phox antibody
Anti-P22 Phagocyte B-Cytochrome antibody
Anti-CYBB antibody
Anti-NOX2 antibody

Information sourced from Uniprot.org