| Tissue Specificity | Detected in neutrophils (at protein level). |
| Post Translational Modifications | Glycosylated. Phosphorylated on Ser and Thr residues. Undergoes 'Lys-48'-linked polyubiquitination, likely by RNF145, triggering endoplasmic reticulum-associated degradation. |
| Function | Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. |
| Protein Name | Cytochrome B-245 Heavy ChainCgd91-PhoxCytochrome B(558 Subunit BetaCytochrome B558 Subunit BetaHeme-Binding Membrane Glycoprotein Gp91phoxNadph Oxidase 2Neutrophil Cytochrome B 91 Kda PolypeptideSuperoxide-Generating Nadph Oxidase Heavy Chain SubunitGp91-1Gp91-PhoxP22 Phagocyte B-Cytochrome |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-1236973Reactome: R-HSA-3299685Reactome: R-HSA-4420097Reactome: R-HSA-5668599Reactome: R-HSA-6798695Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinAs Unassembled Monomer May Localize To The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Cytochrome B-245 Heavy Chain antibodyAnti-Cgd91-Phox antibodyAnti-Cytochrome B(558 Subunit Beta antibodyAnti-Cytochrome B558 Subunit Beta antibodyAnti-Heme-Binding Membrane Glycoprotein Gp91phox antibodyAnti-Nadph Oxidase 2 antibodyAnti-Neutrophil Cytochrome B 91 Kda Polypeptide antibodyAnti-Superoxide-Generating Nadph Oxidase Heavy Chain Subunit antibodyAnti-Gp91-1 antibodyAnti-Gp91-Phox antibodyAnti-P22 Phagocyte B-Cytochrome antibodyAnti-CYBB antibodyAnti-NOX2 antibody |
Information sourced from Uniprot.org
