Anti-CX3CR1 nanobody [11H11] (STJN000631)

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STJN000631
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Cx3c Chemokine Receptor 1 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : 11H11
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Protein A/G purified from cell culture supernatant.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: CX3CR1
Gene ID: 1524
Uniprot ID: CX3C1_HUMAN
Post Translational Modifications This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.
Function Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells.CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. CX3CR1-CX3CL1 signaling mediates cell migratory functions. Responsible for the recruitment of natural killer (NK) cells to inflamed tissues. Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival. Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung. Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells. Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis. Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation. Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli. Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development. Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development. Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi. Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria. Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection. Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis. Isoform 1: (Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein. Isoform 2: (Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein. May have more potent HIV-1 coreceptothr activity than isoform 1. Isoform 3: (Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein. May have more potent HIV-1 coreceptor activity than isoform 1.
Protein Name Cx3c Chemokine Receptor 1
C-X3-C Ckr-1
Cx3cr1
Beta Chemokine Receptor-Like 1
Cmk-Brl-1
Cmk-Brl1
Fractalkine Receptor
G-Protein Coupled Receptor 13
V28
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-9820960
Reactome: R-HSA-9833110
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Nanobody Names Anti-Cx3c Chemokine Receptor 1 nanobody
Anti-C-X3-C Ckr-1 nanobody
Anti-Cx3cr1 nanobody
Anti-Beta Chemokine Receptor-Like 1 nanobody
Anti-Cmk-Brl-1 nanobody
Anti-Cmk-Brl1 nanobody
Anti-Fractalkine Receptor nanobody
Anti-G-Protein Coupled Receptor 13 nanobody
Anti-V28 nanobody
Anti-CX3CR1 nanobody
Anti-CMKBRL1 nanobody
Anti-GPR13 nanobody

Information sourced from Uniprot.org