Anti-CX3CL1 antibody (350-395) {FITC} (STJ500638)

SKU:
STJ500638-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Monkey/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CX3CL1 (350-395) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Cx3cl1
Gene ID: 20312
Uniprot ID: X3CL1_MOUSE
Immunogen Region: 350-395
Immunogen: Synthetic peptide taken within amino acid reigon 350-395 on mouse Fractalkine protein.
Tissue Specificity Highest levels in brain. Lower levels in kidney, heart and lung. Also found in skeletal muscle and testis. Highly expressed in lesional smooth muscle cells, but not macrophages. Low levels of ABCD-3 mRNA were also found in anti-CD40-stimulated splenic B-cells, but not in resting B-cells. Also expressed in dendritic cells.
Post Translational Modifications A soluble short 80 kDa form may be released by proteolytic cleavage from the long membrane-anchored form.
Function Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. Processed fractalkine: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. Fractalkine: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells.
Protein Name Fractalkine
Fk
Abcd-3
C-X3-C Motif Chemokine 1
Cx3c Membrane-Anchored Chemokine
Neurotactin
Small-Inducible Cytokine D1 Cleaved Into - Processed Fractalkine
Database Links Reactome: R-MMU-380108
Reactome: -MMU-418594
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Processed Fractalkine: Secreted
Alternative Antibody Names Anti-Fractalkine antibody
Anti-Fk antibody
Anti-Abcd-3 antibody
Anti-C-X3-C Motif Chemokine 1 antibody
Anti-Cx3c Membrane-Anchored Chemokine antibody
Anti-Neurotactin antibody
Anti-Small-Inducible Cytokine D1 Cleaved Into - Processed Fractalkine antibody
Anti-Cx3cl1 antibody
Anti-Cx3c antibody
Anti-Fkn antibody
Anti-Scyd1 antibody

Information sourced from Uniprot.org

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