| Function | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor.binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer.may require the basic helix-loop-helix protein TCF4 as a coactivator. CDP/Cux p110: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. |
| Protein Name | Homeobox Protein Cut-Like 1Ccaat Displacement ProteinCdpCdp/Cux P200Homeobox Protein Cux-1 Cleaved Into - Cdp/Cux P110 |
| Database Links | Reactome: R-HSA-6811438Reactome: R-HSA-1839117Reactome: R-HSA-5655302 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Cut-Like 1 antibodyAnti-Ccaat Displacement Protein antibodyAnti-Cdp antibodyAnti-Cdp/Cux P200 antibodyAnti-Homeobox Protein Cux-1 Cleaved Into - Cdp/Cux P110 antibodyAnti-CUX1 antibodyAnti-CUTL1 antibody |
Information sourced from Uniprot.org
