| Function | Core component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes, also named CRL5 complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Acts a scaffold protein that contributes to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable SOCS box-containing substrate recognition component. Acts as a key regulator of neuron positioning during cortex development: component of various SOCS-containing ECS complexes, such as the ECS(SOCS7) complex, that regulate reelin signaling by mediating ubiquitination and degradation of DAB1. ECS(SOCS1) seems to direct ubiquitination of JAK2. The ECS(SOCS2) complex mediates the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR. The ECS(SPSB3) complex catalyzes ubiquitination of nuclear CGAS. ECS(KLHDC1) complex is part of the DesCEND (destruction via C-end degrons) pathway and mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine. The ECS(ASB9) complex mediates ubiquitination and degradation of CKB. As part of some ECS complex, promotes 'Lys-11'-linked ubiquitination and degradation of BTRC. As part of a multisubunit ECS complex, polyubiquitinates monoubiquitinated POLR2A. May form a cell surface vasopressin receptor. (Microbial infection) Following infection by HIV-1 virus, CUL5 associates with HIV-1 Vif proteins and forms a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) that catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G. The complex can also ubiquitinate APOBEC3H to some extent. (Microbial infection) Seems to be involved in proteasomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. |
| Protein Name | Cullin-5Cul-5Vasopressin-Activated Calcium-Mobilizing Receptor 1Vacm-1 |
| Database Links | Reactome: R-HSA-180585Reactome: R-HSA-8863795Reactome: R-HSA-8951664Reactome: R-HSA-9705462Reactome: R-HSA-983168Reactome: R-HSA-9833109 |
| Cellular Localisation | NucleusLocalizes To Sites Of Dna Damage In A Ubap2 And Ubap2l-Dependent Manner |
| Alternative Antibody Names | Anti-Cullin-5 antibodyAnti-Cul-5 antibodyAnti-Vasopressin-Activated Calcium-Mobilizing Receptor 1 antibodyAnti-Vacm-1 antibodyAnti-CUL5 antibodyAnti-VACM1 antibody |
Information sourced from Uniprot.org
