| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CTSE (132-244) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CTSE |
| Gene ID: |
1510 |
| Uniprot ID: |
CATE_HUMAN |
| Immunogen Region: |
132-244 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 132-244 of human Cathepsin E (CTSE) (P14091). |
| Immunogen Sequence: |
GQSFSIQYGTGSLSGIIGAD QVSVEGLTVVGQQFGESVTE PGQTFVDAEFDGILGLGYPS LAVGGVTPVFDNMMAQNLVD LPMFSVYMSSNPEGGAGSEL IFGGYDHSHFSGS |
| Tissue Specificity | Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes. |
| Post Translational Modifications | Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide. Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57. |
| Function | May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. |
| Protein Name | Cathepsin E Cleaved Into - Cathepsin E Form I - Cathepsin E Form Ii |
| Database Links | Reactome: R-HSA-2132295 |
| Cellular Localisation | EndosomeThe Proenzyme Is Localized To The Endoplasmic Reticulum And Golgi ApparatusWhile The Mature Enzyme Is Localized To The Endosome |
| Alternative Antibody Names | Anti-Cathepsin E Cleaved Into - Cathepsin E Form I - Cathepsin E Form Ii antibodyAnti-CTSE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and LRRC59 knockout (KO) 293T cells, using [KO Validated] LRRC59 Rabbit polyclonal antibody (STJ11100841) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89775/358247/STJ11100841_1__11256.1713122582.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and LRRC59 knockout (KO) 293T cells, using [KO Validated] LRRC59 Rabbit polyclonal antibody (STJ11100841) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.")