| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CTSB |
| Gene ID: | 1508 |
| Uniprot ID: | CATB_HUMAN |
| Immunogen Region: | 18-339 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-339 of human Cathepsin B (NP_001899.1). |
| Immunogen Sequence: | RSRPSFHPLSDELVNYVNKR NTTWQAGHNFYNVDMSYLKR LCGTFLGGPKPPQRVMFTED LKLPASFDAREQWPQCPTIK EIRDQGSCGSCWAFGAVEAI SDRICIHTNAHVSVEVSAED LLTCCGSMCGDGCNGGYPAE AWNFWTRKGLVSGGLYESHV GCRPYSIPPCEHHVNGSRPP CTGEGDTPKCSKICEPGYSP TYKQDKHYGYNSYSVSNSEK DIMAEIYKNGPVEGAFSVY |
| Tissue Specificity | Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum. |
| Function | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis. |
| Protein Name | Cathepsin BApp SecretaseAppsCathepsin B1 Cleaved Into - Cathepsin B Light Chain - Cathepsin B Heavy Chain |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1679131Reactome: R-HSA-2022090Reactome: R-HSA-2132295Reactome: R-HSA-6798695 |
| Cellular Localisation | LysosomeMelanosomeSecretedExtracellular SpaceApical Cell MembranePeripheral Membrane ProteinExtracellular SideIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvLocalizes To The Lumen Of Thyroid Follicles And To The Apical Membrane Of Thyroid Epithelial Cells |
| Alternative Antibody Names | Anti-Cathepsin B antibodyAnti-App Secretase antibodyAnti-Apps antibodyAnti-Cathepsin B1 Cleaved Into - Cathepsin B Light Chain - Cathepsin B Heavy Chain antibodyAnti-CTSB antibodyAnti-CPSB antibody |
Information sourced from Uniprot.org
