| Short Description : | Mouse monoclonal anti-cTnI (C-Term) for use in FIA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | FIA |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | 9707 |
| Isotype: | IgG1 |
| Conjugation: | Unconjugated |
| Concentration: | 5.0 mg/ml (+/-10 %) |
| Formulation: | 50 mM citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative |
| Storage Instruction: | Store at 2–8 °C, and do not freeze. |
| Immunogen: | In the C-terminal part of the cTnI molecule (residues 190-195) |
| Immunogen Region: | C-Term |
| Specificity: | Antibody recognizes human cardiac troponin I (cTnI). Skeletal troponin I (sTnI) 14 % Does not recognize cardiac troponin T (cTnT) , cardiac troponin C (cTnC) , or skeletal troponin T (sTnT) |
| Post Translational Modifications | Phosphorylated at Ser-42 and Ser-44 by PRKCE.phosphorylation increases myocardium contractile dysfunction. Phosphorylated at Ser-23 and Ser-24 by PRKD1.phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). |
| Function | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| Protein Name | Troponin I - Cardiac MuscleCardiac Troponin I |
| Database Links | Reactome: R-HSA-390522Reactome: R-HSA-5578775 |
| Alternative Antibody Names | Anti-Troponin I - Cardiac Muscle antibodyAnti-Cardiac Troponin I antibodyAnti-TNNI3 antibodyAnti-TNNC1 antibody |
Information sourced from Uniprot.org
