| Tissue Specificity | Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma. |
| Post Translational Modifications | Sumoylated with SUMO1. |
| Function | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus. Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes. Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element. May also function in the P53-signaling pathway. |
| Protein Name | B-Cell Lymphoma/Leukemia 11bBcl-11bB-Cell Cll/Lymphoma 11bCoup-Tf-Interacting Protein 2Radiation-Induced Tumor Suppressor Gene 1 ProteinHrit1 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-B-Cell Lymphoma/Leukemia 11b antibodyAnti-Bcl-11b antibodyAnti-B-Cell Cll/Lymphoma 11b antibodyAnti-Coup-Tf-Interacting Protein 2 antibodyAnti-Radiation-Induced Tumor Suppressor Gene 1 Protein antibodyAnti-Hrit1 antibodyAnti-BCL11B antibodyAnti-CTIP2 antibodyAnti-RIT1 antibody |
Information sourced from Uniprot.org
