| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Casein Kinase Ii Subunit Alpha (1-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CSNK2A2 |
| Gene ID: |
1459 |
| Uniprot ID: |
CSK22_HUMAN |
| Immunogen Region: |
1-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CSNK2A2 (NP_001887.1). |
| Immunogen Sequence: |
MPGPAAGSRARVYAEVNSLR SREYWDYEAHVPSWGNQDDY QLVRKLGRGKYSEVFEAINI TNNERVVVKILKPVKKKKIK REVKILENLRGGTNIIKLID TVKDPVSKTPALVFEYINNT DFKQLYQILTDFDIRFYMYE LLKALDYCHSKGIMHRDVKP HNVMIDHQQKKLRLIDWGLA EFYHPAQEYNVRVASRYFKG PELLVDYQMYDYSLDMWSLG CMLASMIFRREPFFHGQDN |
| Function | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. |
| Protein Name | Casein Kinase Ii Subunit Alpha'Ck Ii Alpha' |
| Database Links | Reactome: R-HSA-1483191Reactome: R-HSA-201688Reactome: R-HSA-2514853Reactome: R-HSA-445144Reactome: R-HSA-6804756Reactome: R-HSA-6814122Reactome: R-HSA-8934903Reactome: R-HSA-8939243Reactome: R-HSA-8948751Reactome: R-HSA-9755511 |
| Cellular Localisation | NucleusCytoplasmInteraction With Sirt6 Prevents Translocation Into The Nucleus |
| Alternative Antibody Names | Anti-Casein Kinase Ii Subunit Alpha' antibodyAnti-Ck Ii Alpha' antibodyAnti-CSNK2A2 antibodyAnti-CK2A2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
