| Post Translational Modifications | Autophosphorylated. Phosphorylated by aPKC which promotes dissociation from the cell cortex. |
| Function | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. Involved in regulation of reactive oxygen species (ROS) levels. |
| Protein Name | Casein Kinase I Isoform Gamma-2Cki-Gamma 2 |
| Database Links | Reactome: R-HSA-1660661Reactome: R-HSA-4641262 |
| Cellular Localisation | CytoplasmCell Cortex |
| Alternative Antibody Names | Anti-Casein Kinase I Isoform Gamma-2 antibodyAnti-Cki-Gamma 2 antibodyAnti-CSNK1G2 antibodyAnti-CK1G2 antibody |
Information sourced from Uniprot.org
